African Natural Products Database (ANPDB)
The update of data is ongoing. ANPDB summarizes all our past projects on natural product libraries from African sources, including AfroDb, p-ANAPL, NANPDB, EANPDB, AfroCancer, AfroMalariaDB, Afrotryp, etc. The link to the online database is available here.
AvH Research Group Linkage
Discovery of anti-HIV pseudo-natural products with latency reversal properties, is an ongoing project in partnership with Prof. Wolfgang Sippl, Martin-Luther University Halle-Wittenberg (Germany). It is a Research Group Linkage Project, funded by the Alexander von Humboldt Foundation.
Nature-inspired Discovery of Novel Antivirals (NiDNA)
The NiDNA project is currently being funded as a Calestous Juma Science Leadership Fellowship awarded to the PI, in partnership with Ersilia (UK) and the Wistar Institute (USA), by the Bill & Melinda Gates Foundation. The funding information is published here.
African-derived Natural Products Box (AdNPB)
In collaboration with Medicines for Malaria Venture (MMV), we are preparing a collection of diverse natural compounds from African medicinal plants for screening in diverse assays. This project is being jointly funded by the Bill & Melinda Gates Foundation and LifeArc
Selected Publications
OUR RESEARCH OUTPUTS
2024
- Shu VA, Eni DB, Ntie-Kang F. (2024) A survey of isatin hybrids and their biological properties. Mol Divers . https://doi.org/10.1007/s11030-024-10883-z
- Eni DB, Cassel J, Namba-Nzanguim CT, Simoben CV, Tietjen I, Akunuri R, Salvino JM, Ntie-Kang F.(2024) Design, synthesis, and biochemical and computational screening of novel oxindole derivatives as inhibitors of Aurora A kinase and SARS-CoV-2 spike/host ACE2 interaction. Med Chem Res 33, 620–634 . https://doi.org/10.1007/s00044-024-03201-7.
- Ntie-Kang F, Eni DB, Telukunta KK, Osamor VC, Egieyeh SA, Duran-Frigola M, Mishra P, Shadrack DM, Paul L, Musyoka TM, Blin K, Farid MM, Chen Y, Djogang LK, Betow JY, Ibezim A, Joshi D, Edwin AT, Chama MA, Ongagna JM, Kemdoum S, Pierre V, Metuge JA, Bekono BD, Isa MA, Medina-Franco José L, Weber T, Dorrestein PC, Janezic DB, Özlem T, Ludwig-Müller J. (2024) The workshops on computational applications in secondary metabolite discovery (CAiSMD). Physical Sciences Reviews, . https://doi.org/10.1515/psr-2024-0015.
2023
- Namba-Nzanguim CT, Turon G, Simoben CV, Tietjen I, Montaner LJ, Efange SMN, Duran-Frigola M, Ntie-Kang F. (2022) Artificial intelligence for antiviral drug discovery in low resourced settings: A perspective. Frontiers in Drug Discovery, 2:1013285.
- Babiaka SB, Onguene PA, Bekono BD, Ntie-Kang F. (2022) In silico and Computational Analysis of Plant Secondary Metabolites from African Medicinal Plants. In Applications in Plant Biotechnology: Focus on Plant Secondary Metabolism and Plant Molecular Pharming. Makzhoum, A.; Hefferon, K. (Editors). 2022, CRC Press Taylor & Francis: ISBN: 9780367344467.
2021
- Ebob OT, Babiaka SB, Ntie-Kang F. (2021) Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2. Natural Products and Bioprospecting, 11:611-628.
- Ibezim A, Onuku RS, Ibezim A, Ntie-Kang F, Nwodo NJ, Adikwu MU (2021) Structure-based virtual screening and molecular dynamics simulation studies to discover new SARS-CoV-2 main protease inhibitors. Scientific African, 14:e00970.
Names of authors currently working at UB-CeDD are highlighted in bold.
The PI's publications before the creation of UB-CeDD.
The full publications list of the PI is available here